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Sterile single-use containers. Extra-strength relief plus protection. No preservatives. Refresh Brand is the number 1 doctor recommended. (Verispan's Physician Drug & Diagnosis Audit (PDDA) February 2000 - January 2005.) Ideal for moderate-to-severe dry eye, Refresh Celluvisc Lubricant Eye Drops soothes your eyes with a special, thicker formula that contains many of the same healthy qualities as natural tears. This effective, extra-strength eye drop is also preservative-free for sensitive eyes, and can be used as often as needed to provide 24-hour comfort. What Can Cause Dry Eye? Heating and air conditioning; Computer use and reading; Wind and sun; Certain medications; Age and certain medical conditions. Made in Ireland.