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Ensure Plus nutrition shakes are clinically proven to help gain weight. Each shake contains 16 grams of high-quality protein, 350 calories, 27 vitamins and minerals, and nutrients to support immune-system health, including vitamins A and D, zinc, and antioxidants.* Ensure Plus protein shakes provide complete, balanced nutrition and are a great meal replacement option! * Vitamins C and E. † Ensure Plus = 16 g protein per 8 fl oz vs Ensure Original = 9 g protein per 8 fl oz.